Homi is the Anne F. Rothenberg Professor of the Humanities in the English and Comparative Literature Departments at Harvard University. He was founding director of the Mahindra Humanities Center at Harvard University and director of the Harvard Humanities Center. He is the author of numerous works exploring postcolonial theory, cultural change and power, contemporary art, and cosmopolitanism. Homi is also leading a research project on the Global Humanities supported by the Volkswagen and Mellon Foundations. He is a member of the Academic Committee for the Shanghai Power Station of Art, advisor on the Contemporary and Modern Art Perspectives (CMAP) project at New York's Museum of Modern Art, and Curator in Residence of the Boston Museum of Fine Arts. In 2012, Homi was awarded the Government of India’s Padma Bhushan Presidential Award in the field of literature and education. He holds honorary degrees from Université Paris 8, University College London, the Free University Berlin, and Stellenbosch University in South Africa. Early in 2020, Homi was elected as Fellow of the British Academy.

At THE NEW INSTITUTE Homi was involved in the program "The Foundations of Value and Values".